*In 1890 George Harley studied a 27-year-old who also exerted reddish urine and an "unusual nerve disturbance after taking sulphonal.
*In 1898 McCall Anderson described two brothers had eruptions with burning and pruitus on the sun exposed areas of their skin so severe that they lost part of their ears and nose. They exhibited dark urine.
*Alfred F. Harris demonstrated that the urine of both brothers contained the hematoporphyrin group.
*Dr. Max Dobrschansky described the first case of acute porphyria after a patient had a barbiturate
*H. Gunther classified the diseases of porphyria, including congenital erythropoietic porphyria (CEP), which he called congenital hepatoporphyria, the most rare porphyria in 1911.
*Dr. Friedrich Meyer Betz injected himself with hematoporphyrins to determine their photodynamic impact. He subjected himself to the sun and became so photosensitive that the extremely painful photosensitive effect lasted several months. The photos of Dr. Betz taken hours after he injected himself illustrated his badly swollen face. He was unrecognizable until the swelling decreased. The experiment is used today in dermatology textbooks.
*Hans Fischer studied one of H. Gunther's patients, Mr. Petry, who had the rare type of Porphyria, CEP. Using data from Mr. Petry's case, Fischer provided significant insight into the chemistry of porphyrins. He also found that uroporphyrins and coproporphyrins were different from hematoporphyrins and subsequently suggested that the hemato prefix be dropped.
* A.E. Garrod credits H. Gunther with first recognizing that hematoporphyria was, in fact, an inherited metabolic problem in his manuscript, Inborn Errors of Metabolism. This is the first time the term "inborn errors" of metabolism had been ever used for a group of inherited metabolic disorders and the year CEP was first identified.
* Dr. Jan G. Waldenstorm suggested theta the name of the disease of porphyrin metabolism be porphyries rather than Hematoporphyrias. Using Paul Ehrlich's aldehyde reagent, Waldenstorm identified 103 patients with acute porphyria by testing their urine and noting the red color. He discovered that asymptomatic family members of these patients also had the same reaction if they ingested even small amounts of barbiturates and sulphonal.
*In 1898 McCall Anderson described two brothers had eruptions with burning and pruitus on the sun exposed areas of their skin so severe that they lost part of their ears and nose. They exhibited dark urine.
*Alfred F. Harris demonstrated that the urine of both brothers contained the hematoporphyrin group.
*Dr. Max Dobrschansky described the first case of acute porphyria after a patient had a barbiturate
*H. Gunther classified the diseases of porphyria, including congenital erythropoietic porphyria (CEP), which he called congenital hepatoporphyria, the most rare porphyria in 1911.
*Dr. Friedrich Meyer Betz injected himself with hematoporphyrins to determine their photodynamic impact. He subjected himself to the sun and became so photosensitive that the extremely painful photosensitive effect lasted several months. The photos of Dr. Betz taken hours after he injected himself illustrated his badly swollen face. He was unrecognizable until the swelling decreased. The experiment is used today in dermatology textbooks.
*Hans Fischer studied one of H. Gunther's patients, Mr. Petry, who had the rare type of Porphyria, CEP. Using data from Mr. Petry's case, Fischer provided significant insight into the chemistry of porphyrins. He also found that uroporphyrins and coproporphyrins were different from hematoporphyrins and subsequently suggested that the hemato prefix be dropped.
* A.E. Garrod credits H. Gunther with first recognizing that hematoporphyria was, in fact, an inherited metabolic problem in his manuscript, Inborn Errors of Metabolism. This is the first time the term "inborn errors" of metabolism had been ever used for a group of inherited metabolic disorders and the year CEP was first identified.
* Dr. Jan G. Waldenstorm suggested theta the name of the disease of porphyrin metabolism be porphyries rather than Hematoporphyrias. Using Paul Ehrlich's aldehyde reagent, Waldenstorm identified 103 patients with acute porphyria by testing their urine and noting the red color. He discovered that asymptomatic family members of these patients also had the same reaction if they ingested even small amounts of barbiturates and sulphonal.